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Novak Djokovic avoided a shock fourth-round exit at the French Open after fighting back from two sets down against teenager Lorenzo Musetti.

The world number one was outplayed early on before rallying, leading 6-7 (7-9) 6-7 (2-7) 6-1 6-0 4-0 when the 19-year-old Italian retired injured.

World number 76 Musetti, playing in his first Grand Slam main draw, was given a standing ovation as he left the court.

Rafael Nadal also made the last eight, beating Jannik Sinner 7-5 6-3 6-0.

The 13-time French Open champion recovered from an opening-set wobble in which he twice dropped serve to trail 5-3 to comfortably see off the Italian 18th seed and extend his winning run in Paris to 35 sets.

Djokovic's victory, meanwhile, marked the fifth occasion he has overturned a two-set deficit to win at a Slam.

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World number one Novak Djokovic will not defend his Madrid Open title after pulling out of next month's event.

The Serb, 33, said he was sorry he would not be able to travel to Madrid for the Masters 1000 event which starts on Sunday, four weeks before the French Open

"It's been two years already, quite a long time," he added. "Hope to see you all next year."

Last year's Madrid event was cancelled because of the coronavirus pandemic.

Djokovic was stunned last weekend by Russian world number 28 Aslan Karatsev in the semi-finals of the Serbia Open and earlier this month lost to Britain's Dan Evans in Monte Carlo.

The Serb won his 18th Grand Slam title in February with victory at the Australian Open.

He is expected to play in Rome and Belgrade next month as part of his preparations for the French Open, which starts on 30 May.