Sadio Mane slotted home the winning penalty in a shootout to send Senegal to the 2022 World Cup after Liverpool team-mate Mohamed Salah missed his spot-kick for Egypt.
In a repeat of the Africa Cup of Nations final, Senegal were left the 'happier' side at the final whistle after winning the game on penalties, with Egypt's players disappointed and Salah - one of the world's best players - left contemplating his absence from November's tournament in Qatar.
The second leg of the play-off tie in Senegal's new 50,000-seater stadium finished 1-0 to the hosts and 1-1 on aggregate after extra time, sending the game to a tense and dramatic shootout.
Mane had previously scored the penalty which won the Nations Cup and the Reds forward didn't fail to net the decisive spot-kick once again after keeper Edouard Mendy had given Senegal an advantage by saving from Mostafa Mohamed at 2-1.
Egypt captain Salah was one of four players to miss the first four penalties of a shootout marked by a vast number of green laser pointers aimed at the visiting players and goalkeeper from the home supporters.
Senegal's Boulaye Dia was the scorer of the only goal in normal time – claiming the first goal after just four minutes with a shot that hit the body of Pharaohs defender Hamdi Fathi.
Elsewhere in Africa's World Cup play-offs, Ghana, Tunisia, Morocco and Cameroon also clinched qualification - with Nigeria, Mali, DR Congo and Algeria all eliminated.
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