A Nicolas Jackson hat-trick and Cole Palmer's spot kick saw Chelsea hammer nine-man Tottenham Hotspur 4-1 in a chaotic Monday night clash.
Dejan Kulusevski's deflected shot put Spurs ahead after six minutes, but it went into reverse at alarming speed when Cristian Romero returned to his old reckless ways.
The Blues were fortunate to escape a sending-off for kicking out at Levi Cowell. Still, they could not resist following through on international teammate Enzo Fernandez, picking up a red card, and allowing Cole Palmer to equalise from the spot in 35 minutes.
Spurs' night went rapidly downhill as Van de Venn collapsed, clutching his hamstring as he raced back to halt a Chelsea attack, before Maddison also went off after appearing to pick up an ankle injury.
Unlike Romero, Destiny Udogie was lucky to escape a red card for an early lunge on Raheem Sterling. Still, a rash, late dive into another tackle early in the second half on the same player left referee Oliver no option but to send him off.
Chelsea took advantage and went 2-1 ahead through Jackson in the 75th minute.
In the 94th minute, Jackson grabbed his second of the night to put Chelsea 3-1 ahead.
The Senegalese then completed his hat-trick as he netted in 97 minutes.
A win for Spurs would have seen them return to the top, as they remain in second place with 26 points, while Chelsea moves up to 10th with 15 points.