Anthony Joshua’s bid to make a splash in his US debut ended in misery for the three belt heavyweight world champion with a stunning loss to underdog Andy Ruiz at Madison Square Garden on Saturday.

Ruiz recorded a monster upset, by knocking down Britain’s Joshua four times to take the World Boxing Association, International Boxing Federation and World Boxing Organization titles.

The 29-year-old Ruiz came into the fight as a massive 32-1 underdog. But he won it by TKO in the middle of the seventh when the referee stopped it at 1:26 of the round after the fourth knockdown.

Ruiz, sent to the canvas once himself, knocked Joshua down twice in the third round and twice more in the seventh.

“I still can’t believe it. I am still pinching myself to see if this is real,” Ruiz said.

Ruiz (33-1, 22 KOs) has been underestimated because of his physique, but he knew what was at stake and how fortunate he was to get a second chance at a world title.

He was a late replacement for Jarrell Miller, who withdrew from the bout with Joshua after failing three drug tests in April.

“Everything is possible man. Look at me, I just made history,” Ruiz said.

USA’s Andy Ruiz (off frame) knocks down England’s Anthony Joshua during their 12-round IBF, WBA, WBO & IBO World Heavyweight Championship fight at Madison Square Garden in New York on June 1, 2019.

Ruiz, who was born in San Diego and carries a US passport, considers himself Mexican and is now the first heavyweight champion of Mexican descent.

“I think Mexico has a champ in every weight and now we have a heavyweight champion. I am so happy,” said Ruiz.