Birmingham will host 72 teams and approximately 6,500 athletes and officials for the largest sporting program in Commonwealth Games history over the next 12 days.
For the first time at a major multi-sport event, women will outnumber men in medal events 136-134.
The Games also include a record 42 Para-sports event.
The opening ceremony will take place at Alexander Stadium on Thursday.
The live action begins on Friday, with women's Twenty20 cricket, three-on-three basketball, and mixed synchronized swimming among the new sports to be featured.
With 1.2 million tickets already sold, it is expected to be the most-attended Games ever.
With 1.2 million tickets already sold, it is anticipated to be the most crowded Games.
15 locations in the West Midlands will host the action, with one being the Lee Valley velodrome in London, where track cycling will be featured.
Olympic medalists from Great Britain Laura Kenny and Adam Peaty will participate for England in the cycling and swimming sports, while Geraint Thomas, who placed third in the Tour de France, will ride for Wales.
Shelly-Ann Fraser-Pryce, a sprinting sensation from Jamaica who just won the 100-meter global championship, will try to add an individual Commonwealth gold medal to her illustrious resume.
Ariarne Titmus, who completed the 400m-800m freestyle double at the Olympics in Tokyo, will represent Australia in the pool.
Flora Duffy, an Olympic triathlon winner from Bermuda, is anticipated to compete against Georgia Taylor-Brown of England in the women's race. Amongst others.