Atletico Madrid moved three points clear at the top of La Liga thanks to victory at third-placed Real Sociedad.
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Mario Hermoso's header broke the deadlock early in the second half before Marcos Llorente's cool finish sealed victory for Diego Simeone's men.
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Atletico, who have conceded just five goals in 13 league games this term, comfortably kept an eighth clean sheet.
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Real Madrid could draw level on points if they beat Granada on Wednesday but will have played two games more.
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Zinedine Zidane's Real are the only side to have inflicted a domestic defeat on Atletico this season.