Atletico Madrid moved three points clear at the top of La Liga thanks to victory at third-placed Real Sociedad.
Mario Hermoso's header broke the deadlock early in the second half before Marcos Llorente's cool finish sealed victory for Diego Simeone's men.
Atletico, who have conceded just five goals in 13 league games this term, comfortably kept an eighth clean sheet.
Real Madrid could draw level on points if they beat Granada on Wednesday but will have played two games more.
Zinedine Zidane's Real are the only side to have inflicted a domestic defeat on Atletico this season.