Barcelona played a 1-1 draw with Atletico Madrid at Camp Nou on Wednesday.
Ivan Rakitic’s first-half goal was cancelled out by Angel Correa as the La Liga rivals shared the spoils on the night.
Rakitic headed the defending champions in front just before half-time — and the second half saw Sergio Busquets exit in the 51st minute with the flu and Messi leave with a groin problem in the 59th, before Angel Correa equalised in the 61st minute almost immediately after his fellow Argentine’s departure.
Real Madrid missed the chance to make La Liga history as they were held to a 1-1 draw by Villarreal at the Bernabeu.
Sunday’s victory over Espanyol made it 16 league wins in a row for Los Blancos stretching back to March, equalling the all-time mark set by Pep Guardiola’s Barcelona in the 2010-11 season.
But Zinedine Zidane’s men were unable to secure the record outright as they fell behind to a Bruno Soriano penalty given for a Sergio Ramos handball on the stroke of half-time. Soriano scored with an expertly executed Panenka spot kick.
Ramos made amends when he levelled three minutes into the second period with a towering header and Real dominated after a hesitant first 45 minutes, but could not find a second goal.
Real Sociedad romped to a comfortable 4-1 victory over early interesting in form side Las Palmas at the Estadio Anoeta on Wednesday night.
The result left Real Sociedad in eighth, three places and two points behind Las Palmas in 6th.