Italian champions, Juventus had their perfect start to the Serie A season terminated after suffering a 2-1 loss to Inter Milan at the San Siro on Sunday evening.
Inter were widely expected to push Juventus for the title this season, but they had made an unconvincing start to their campaign, picking up just four points from their first three matches.
The Nerazurri looked set for more misery when Stephan Lichtsteiner put Juventus ahead in the 66th minute, but Mauro Icardi equalised for the hosts just two minutes later with a header from a corner.
Substitute Ivan Perisic headed Inter in front after fine work from Icardi, and Juve – with Gonzalo Higuain on from the bench – could not find an equalizer, despite Ever Banega’s late red card.
The result was only Juve’s second Serie A defeat since they lost 1-0 to Sassuolo on 28 October, 2015.
The champions slip to second on the log, behind Napoli, while Inter move up to sixth.