French Open champion Garbine Muguruza and Wimbledon finalist Milos Raonic made shock exits in the second round of the US Open.
Canada’s Raonic, the fifth seed, struggled physically as American qualifier Ryan Harrison – the world number 120 – won 6-7 (4-7) 7-5 7-5 6-1.
Spanish third seed Muguruza lost 7-5 6-4 to Latvia’s Anastasija Sevastova.
Elsewhere in Round 2 action of Day 3, Top seed Novak Djokovic reached round three without hitting a ball as Jiri Vesely withdrew before their match due to inflammation of his left forearm.
Former champion Marin Cilic and French seeds Gael Monfils and Jo-Wilfried Tsonga progressed, alongside fourth seed Rafael Nadal on Wednesday.
In the Women’s half Seventh seed Roberta Vinci defeated Christina McHale 6-1, 6-3, American and Eight seed Madison Keys beat fellow American Kayla Day 6-1, 6-1 with ninth seed Svetlana Kuznetsova was beaten by unseeded Caroline Wozniacki.